The centre-back missed the midweek win over Tottenham Hotspur due to the back spasm that had forced him off at half-time against Fulham the previous Sunday.
But Matip has since returned to full training and Jürgen Klopp expects him to be in contention for the lunchtime kick-off at Selhurst Park.
“Joel trained yesterday completely normal, so it looks like,” said the boss on Friday morning.
“I’m not 100,000 per cent sure but it looks like.”