The 8pm GMT kick-off at St Mary's will be broadcast live on Sky Sports in the UK.
Extended highlights will be available to watch on LFCTV GO from midnight.
Make sure you don’t miss a kick of the action this season by using the code 2021GOFREE to start a free one-month trial of LFCTV GO now – this can be cancelled at any time.
Our Match Centre will begin on Monday morning on Liverpoolfc.com and the official LFC app, bringing you all the build-up to the game, minute-by-minute updates, audio commentary, interactive features and much more.
For global broadcast listings, click here.