Rhys Williams begins in defence at Old Trafford, while James Milner returns in midfield.
Mohamed Salah, Roberto Firmino and Curtis Jones are also drafted into the starting line-up for the champions.
Liverpool: Alisson, Alexander-Arnold, R. Williams, Fabinho, Robertson, Thiago, Wijnaldum, Milner, Jones, Salah, Firmino.
Subs: Kelleher, Mane, Oxlade-Chamberlain, Minamino, Tsimikas, Shaqiri, Origi, Phillips, N. Williams.