The captain will feature for the 286th time for the club in the top flight should he be selected at West Ham United.
That would move Henderson beyond Reina and behind only Jamie Carragher (508 games), Steven Gerrard (504) and Sami Hyypia (318) for the Reds in the division.
For more pre-match facts and figures from LFC statistician Ged Rea, read on…
Liverpool have won 30 of the 49 meetings between the clubs in the Premier League, and have lost just nine of the last 64 clashes in the top flight.
The Reds are unbeaten in their last four trips to West Ham (three wins, one draw) and have scored in 10 of their 11 most recent visits.
Jürgen Klopp’s team have not conceded more than once in any of their last 15 Premier League fixtures.
Mohamed Salah, Gerrard and Michael Owen (seven each) have scored the most Premier League goals for Liverpool against the Hammers.
Salah could become the first Reds player since Billy Liddell in 1958 to net in a fourth consecutive league match versus West Ham.
The No.11 goes into this afternoon’s game one shy of becoming the fifth Liverpool player in history to score 20 times in four successive seasons.
James Milner - who racked up his 550th Premier League appearance in Thursday’s win at Tottenham Hotspur - made his senior professional debut as a 16-year-old substitute for Leeds United against West Ham in November 2002.