Wijnaldum delivered the assist for Steven Berghuis' opener before netting the Netherlands' fourth in their 7-0 win over Gibraltar.
In Group A, Jota scored an equaliser for Portugal as they came from behind to beat Luxembourg 3-1, with the Liverpool forward withdrawn in the 68th minute.
Also in World Cup qualifying action were Ozan Kabak and Neco Williams.
The pair both played 90 minutes as Kabak's Turkey drew 3-3 with Latvia, while Wales recorded a 1-0 victory over the Czech Republic.
Elsewhere, Sadio Mane appeared as a 66th-minute substitute as group winners Senegal concluded their 2022 Africa Cup of Nations qualifying campaign with 1-1 draw against Eswatini.