The Liverpool full-back is one of six nominees for the prestigious annual accolade, which he won in 2020 after helping his side clinch the Premier League title.
This season, Alexander-Arnold was integral to a late-season surge that saw the Reds finish third in the top flight on the back of a 10-game unbeaten run.
He made 45 appearances in all competitions, scoring two goals and providing nine assists, with Jürgen Klopp’s side also reaching the Champions League quarter-finals.
Alexander-Arnold is up against Bukayo Saka (Arsenal), Declan Rice (West Ham United), Mason Greenwood (Manchester United), Mason Mount (Chelsea) and Phil Foden (Manchester City) to retain the award.
The winner, voted by their fellow professionals, will be revealed at the PFA Awards, which take place from 7.30pm BST on Sunday June 6.