The Liverpool midfielder entered the action in the 66th minute of the Group E stalemate in Seville.
Spain are next in action on Saturday when they host Poland at Estadio La Cartuja.
Thiago Alcantara was a second-half substitute as Spain began their Euro 2020 campaign with a 0-0 draw against Sweden on Monday night.
The Liverpool midfielder entered the action in the 66th minute of the Group E stalemate in Seville.
Spain are next in action on Saturday when they host Poland at Estadio La Cartuja.