The centre-back is named in the Reds’ starting XI for a competitive game for the first time since last October after returning to full fitness following knee surgery.
Elsewhere, Kostas Tsimikas replaces the injured Andy Robertson at left-back, while Alex Oxlade-Chamberlain gets the nod in midfield.
Joe Gomez and summer signing Ibrahima Konate are among the substitutes.
Liverpool: Alisson, Alexander-Arnold, Matip, Van Dijk, Tsimikas, Milner, Keita, Oxlade-Chamberlain, Mane, Salah, Jota.
Subs: Kelleher, Fabinho, Konate, Firmino, Gomez, Minamino, Origi, Woodburn, Elliott.