The Spain midfielder begins the Premier League fixture at Elland Road, replacing Jordan Henderson as the Reds make two changes to the team deployed against Chelsea last time out.
The other sees Diogo Jota return for Roberto Firmino, who is ruled out due to a hamstring injury.
Liverpool: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Thiago, Elliott, Mane, Salah, Jota.
Subs: Kelleher, Konate, Milner, Keita, Gomez, Henderson, Oxlade-Chamberlain, Jones, Tsimikas.