The pair – aged 16 and 18, respectively – are named in the Reds’ line-up at Carrow Road, while Tyler Morton and James Balagizi are on the bench.
Ibrahima Konate and Kostas Tsimikas are the only players to retain their places in the starting XI from Saturday’s Premier League win over Crystal Palace.
Joe Gomez is named as captain.
Liverpool: Kelleher, Bradley, Konate, Gomez, Tsimikas, Keita, Jones, Oxlade-Chamberlain, Gordon, Minamino, Origi.
Subs: Adrian, Henderson, Jota, Robertson, Phillips, Morton, Balagizi.