The captain will become the 27th player to reach that milestone should he be selected against FC Porto in the Champions League.
If Henderson features at Estadio do Dragao, he would also become only the 14th man to play 60 games in Europe for the Reds.
For more pre-match facts and figures from LFC statistician Ged Rea, read on…
Should Sadio Mane score, he will join Michael Owen in joint-third place on the club’s all-time European scorers list with 22 goals, with only Steven Gerrard and Mohamed Salah above them
Mane’s next Champions League goal will also see him become only the third Liverpool player to score 20 times in Europe’s premier club competition after Gerrard (30 goals) and Salah (27)
The Reds are aiming to win their opening two games of a Champions League group stage for only the third time
Liverpool are unbeaten in eight previous meetings with Porto (five wins, three draws) and have scored nine goals in their last two visits to the Dragao
The Reds are the only English club to have beaten Porto away more than once and could do so for a third time tonight
Diogo Jota scored his first Liverpool goal a year ago today, the Portuguese coming off the bench to net against Arsenal