The 18-year-old forward is named in the Reds’ starting line-up at Deepdale as Jürgen Klopp makes 11 changes.
Elsewhere, Tyler Morton is handed a full debut in midfield, while there are also berths for Joel Matip, Joe Gomez and Curtis Jones in the XI.
Liverpool: Adrian, Williams, Matip, Gomez, Tsimikas, Morton, Jones, Oxlade-Chamberlain, Blair, Minamino, Origi.
Subs: Hughes, Pitaluga, Konate, Firmino, Jota, Dixon-Bonner, Phillips, Beck, Bradley.