Liverpool's No.11 has won the award for the second successive month following a remarkable streak of form.
Salah scored five goals - a hat-trick in the Reds' 5-0 win at Manchester United and incredible solo strikes against Manchester City and Watford respectively - and provided four assists in four Premier League appearances during October.
He saw off competition from Reece James, Ben Chilwell, Declan Rice, Phil Foden and Conor Gallagher to land the prize again.