Only Alisson Becker, Sadio Mane and Mohamed Salah retain their places from the team deployed at Wolverhampton Wanderers on Saturday.
Tyler Morton is handed a start in midfield, while there are places on the bench for Academy graduates Elijah Dixon-Bonner, James Norris, Max Woltman and Conor Bradley.
Liverpool: Alisson, Williams, Phillips, Konate, Tsimikas, Morton, Oxlade-Chamberlain, Minamino, Mane, Salah, Origi.
Subs: Kelleher, Davies, Fabinho, Keita, Gomez, Robertson, Matip, Dixon-Bonner, Alexander-Arnold, Norris, Woltman, Bradley.