The forward is due to resume training alongside his teammates at the AXA Training Centre on Friday after returning to Merseyside following his triumph with Senegal in the Africa Cup of Nations.
Mane will be assessed by the club’s backroom staff, but Klopp explained he could be involved for the Reds at Turf Moor this weekend.
The manager told his pre-match press conference: “Will Sadio be available? We have to find out.
“Sadio will come [in] this morning for training and I assume he will be in full training and then we make a decision after that on how he feels and all that stuff.
“He will probably still be emotionally high-flying, but physically we have to see how intense the last few days were for him.”