Ibrahima Konate is named in defence at San Siro, while Thiago Alcantara and Harvey Elliott come into midfield.
Diogo Jota returns in attack, with Joel Matip, Jordan Henderson, Naby Keita and Roberto Firmino making way from the starting XI deployed at Burnley on Sunday.
Liverpool: Alisson, Alexander-Arnold, Konate, Van Dijk, Robertson, Fabinho, Thiago, Elliott, Mane, Salah, Jota.
Subs: Kelleher, Milner, Keita, Firmino, Gomez, Henderson, Oxlade-Chamberlain, Minamino, Tsimikas, Diaz, Origi, Matip.