The Reds will definitely be without Thiago Alcantara for the fifth-round tie at Anfield, with the No.6 suffering a hamstring injury during the warm-up for Sunday's Carabao Cup final.
Caoimhin Kelleher started the penalty shootout victory over Chelsea, though is set to make way for Alisson Becker in goal after an intense contest at Wembley.
Klopp said at his pre-match press conference on Tuesday: "We will play a side we have faced already and had some problems. We have to make changes because we played 120 minutes, so we will see who will do that better.”
On Kelleher, he added: "He's not used to 120 minutes and being the hero. There's no need to stress the situation now. No, he will not start tomorrow."
Roberto Firmino has missed the last three matches due to a muscle issue.
For Norwich, Max Aarons and Brandon Williams are doubts for the trip to Merseyside, with Ozan Kabak set to miss out on the meeting with his former club.
Andrew Omobamidele and Adam Idah are long-term absentees, while Grant Hanley is suspended for the fixture.
Canaries boss Dean Smith told reporters: "We have a couple of fresh concerns. Brandon and Max haven't trained yet since the last time. Ozan is struggling with his shoulder, so is unlikely to play.
"The competition allows five subs, so we can chop and change a bit more during the game. There's lots of things we're looking at.
"We want to pick a team that we think has a chance of winning the game."
Last match
Chelsea 0-0 Liverpool (10-11 on pens) on February 27: Kelleher, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Keita, Henderson, Diaz, Salah, Mane.
Southampton 2-0 Norwich City on February 25: Gunn, Aarons, Gibson, Hanley, Gilmour, Normann, Rashica, Williams, Pukki, McLean, Sargent.