Trent Alexander-Arnold and Ibrahima Konate return in defence at Estadio da Luz, while Fabino and Naby Keita are restored in midfield.
Luis Diaz and Sadio Mane join Mohamed Salah in attack, with Joe Gomez, Joel Matip, Jordan Henderson, Curtis Jones, Diogo Jota and Roberto Firmino the players making way from the weekend win over Watford.
Liverpool: Alisson, Alexander-Arnold, Konate, Van Dijk, Robertson, Fabinho, Keita, Thiago, Mane, Diaz, Salah.
Subs: Kelleher, Milner, Firmino, Gomez, Henderson, Oxlade-Chamberlain, Jones, Minamino, Jota, Tsimikas, Matip, Elliott.