The centre-back replaces Nathaniel Phillips in the line-up at Old Trafford, while Jordan Henderson comes into midfield in place of Fabinho.
Roberto Firmino starts, with Darwin Nunez beginning a three-match suspension.
Liverpool: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Henderson, Milner, Elliott, Diaz, Salah, Firmino.
Subs: Adrian, Davies, Fabinho, Tsimikas, Carvalho, Clark, Bajcetic, Phillips, Van den Berg.