The Uruguayan comes into the XI at Etihad Stadium, while Fabio Carvalho also joins the attack.
Fabinho and Jordan Henderson are named among the substitutes.
Liverpool: Kelleher, Milner, Gomez, Matip, Robertson, Bajcetic, Thiago, Elliott, Carvalho, Salah, Nunez.
Subs: Adrian, Fabinho, Keita, Henderson, Oxlade-Chamberlain, Tsimikas, Ramsay, Phillips, Doak.