The striker has been absent from training due to a minor issue and will be checked before the Reds name their squad for the clash with the Seagulls.
"If he cannot train today then, yes, that would rule him out,” Jürgen Klopp told his pre-match press conference on Friday morning.
“We are waiting for the latest information; it is not a major one, but it still kept him out of training. We have to wait for that."
Elsewhere, James Milner and Stefan Bajcetic are set to return to the fold after recovering from respective injuries; however, Roberto Firmino remains absent.
Klopp added: "Millie, yesterday, did big parts of training and will be back in normal training today. Bobby not.
"Stefan will be back in training today. He was out, he got a knock on the hip bone, which is quite uncomfortable, but he will back as well and that's it pretty much."
Firmino has not featured since the resumption of the season in December due to an injury sustained in training.
The manager continued: "In the first moment, it was like a little injury where the estimate [was] 10 days, two weeks
"He did the normal rehab stuff, all the experts told us what we can do - and then Bobby felt again something and that kept him out then for longer.
"I don't know exactly when he will be back, but he's not close to team training, no."