The centre-half has been ruled out of the Premier League fixture at Molineux after sustaining a muscle issue away at Brighton & Hove Albion last weekend.
"Ibou has a muscle injury," Jürgen Klopp told reporters on Friday. "Again he didn’t think it was massive, it happened in the game, I asked him after the game, ‘Are you OK?’ and he said, ‘Yeah, I’m OK.’ After the game [he had] treatment, scan, bam, out."
Elsewhere, Diogo Jota is closing in on a return to full training, while Luis Diaz, Roberto Firmino and Virgil van Dijk also continue to make good progress with their rehabilitation.
The Wolves game is set to come too soon for all four players, however.
Klopp continued: "The boys are training, Diogo Jota had a full session with the team this week but then the next day had again a rehab session, not because of the session the day before, it was just part of the plan. I think he will be back in normal training next week.
“Bobby is getting closer obviously, very good. Luis is running now, it will take a few weeks still but he is now out on the pitch as well running, which is really good.
"Virgil is getting closer, but not ready for the [Wolves] game obviously. Parts of training, I think, next week as well for Virgil."
Mohamed Salah could make his 200th Premier League appearance for the Reds in the 3pm GMT kick-off, with Fabinho one away from that numerical milestone in all competitions.
Meanwhile, Julen Lopetegui is pondering whether to hand debuts to Wolves' new signings Joao Gomes and Craig Dawson.
Lopetegui reported he has no fresh injury concerns within his squad, as Pedro Neto, Boubacar Traore, Chiquinho and Sasa Kalajdzic remain out.
"Obviously, he [Gomes] has just arrived here, and he has to adapt to English football, the environment, the rhythm," the Wolves head coach said.
"In Brazil, they are more or less in the pre-season, so he’s in a different moment to the players and now we have to put him in the same way as the rest of the players as soon as possible.
"Craig wants to be here, we’re happy with him and we are going to build history with him. Once he’s here, he’s a possibility [to play], of course."
Last time out
Brighton & Hove Albion 2-1 Liverpool (January 29): Alisson, Alexander-Arnold, Konate, Gomez, Robertson, Bajcetic, Thiago, Keita, Elliott, Salah, Gakpo.
Manchester City 3-0 Wolverhampton Wanderers (January 22): Sa, Semedo, Collins, Kilman, Bueno, Neves, Nunes, Lemina, Traore, Hwang, Jimenez.