Mohamed Salah's next goal will take him into joint-fifth spot on the club's all-time league goalscorers list, joining Harry Chambers on 135.
The Egyptian needs one more goal to equal John Toshack's club record of 10 goals against West Ham in all competitions.
Liverpool are seeking their 10th league double over the Hammers in the Premier League era and their third in the last four campaigns.
The Reds have defeated West Ham 33 times in the Premier League – against no team have they won more.
Darwin Nunez scored his first home goal for the club in this season's reverse fixture, a 1-0 win at Anfield back in October.
Liverpool have won each of the last two league meetings 1-0. They have never won three in succession by that scoreline.
If he were to score twice in this game Diogo Jota would become the first Red since Luis Suarez in December 2013 to net two goals in three consecutive league games.
If Fabinho receives a yellow card in this fixture he will serve a two-match suspension for accumulating 10 yellow cards before the completion of 32 league games.
The Reds have scored in 12 of their last 13 trips to West Ham.
James Milner's first game in senior football came as a 16-year-old against West Ham in November 2002 as a Leeds United substitute in a 4-3 win.
Fernando Torres, at Anfield in March 2008, is the last Liverpool player to put a hat-trick past the Hammers.