To date, the Egyptian has scored 183 goals in his 299 outings for the Reds in all competitions since arriving from AS Roma in the summer of 2017.
If he nets in the Anfield encounter with Spurs, Salah will move into joint-fifth place on the club's all-time league scorers list – level with Harry Chambers on 135.
Read on for more facts and figures ahead of the 4.30pm BST kick-off...
Liverpool have lost just one of the last 28 Anfield league meetings with Tottenham and are unbeaten in the last 11, winning seven and drawing four.
The Reds are unbeaten in 10 league meetings with Spurs (seven wins and three draws) and if they avoid defeat they will set a new club record of 11 in a row without losing.
Seven of their last nine league wins against Spurs have been decided by a one-goal margin.
Since a 0-0 draw at Tottenham in October 2015, Liverpool have scored in 14 successive Premier League clashes.
A total of 175 goals have been scored in Premier League meetings between Liverpool and Tottenham, with only the Reds' fixtures with Arsenal (184) producing more.
Jürgen Klopp's men are one goal short of recording 50 at Anfield this season.
Diogo Jota has yet to lose a match with Liverpool in which he has scored (30 games).
Salah has scored in each of his last six Anfield appearances in all competitions – netting seven times in that sequence.