Liverpool have won 10 of the last 11 league clashes home and away, scoring 28 times while conceding five, and have won four of the last five meetings at St Mary’s Stadium.
There has been just one goalless draw between the sides at Southampton in 47 league meetings, in November 2016.
The Reds are seeking their 50th league victory over Saints.
Jürgen Klopp’s side’s next goal will be their 100th in all competitions this season.
Should Roberto Firmino come off the bench and score twice he will equal David Fairclough’s club record of 18 goals by a Liverpool substitute in all competitions.
This season, Firmino averages a goal every 138 minutes in all competitions – the best ratio in the Reds’ squad.
Mohamed Salah is one goal shy of scoring 20 in the Premier League for the fifth season out of six with Liverpool – he netted 19 in the other campaign.
Should Salah score at St Mary’s, he will become the first Reds player since Roger Hunt in 1965-66 to net 20 league goals for a third consecutive season.
Only Robbie Fowler (eight) has scored more goals in the Premier League era for Liverpool against Southampton than Salah’s seven.
Salah is one goal away from becoming the first player in Premier League history to provide 20 goals and 10 assists in three seasons – he and Thierry Henry have done so twice.
Alisson Becker and Salah are Liverpool’s only ever-presents in the Premier League this season, with Alisson the only player to have started all 37 matches so far.
The Reds have won each of their last six final day league games since a 1-1 draw at West Bromwich Albion in 2016.