The Reds' last league outing came on November 11, when they defeated Birmingham City 1-0.
Since then Scott Rogers' charges reached the quarter-final of the Continental Tyres Cup, where they lost to Chelsea.
Read on for all of the details ahead of tonight's game...
Where is the game being played? The match is at the Select Security Stadium in Widnes, with kick-off set for 5.30pm GMT.
How can I watch We will have highlights on LFCTV in the coming week. If you plan to attend the game, click here for ticket details.
View from the manager, Scott Rogers
"Our objective at the start of the season was to be competitive in the Women's Super League and I think we have done that. We have shown we can compete with everybody in the league and for us it's one game at a time and our priority now is to start 2018 in fine style with the three points against Yeovil. At the end of the season the table never really lies and hopefully if we get our performances right we will be right up there at the front of the table.
"Yeovil might be bottom of the Women's Super League and lost all of their games so far, but we will certainly not go into this game thinking it will be easy, far from it. I've watched their games and they are a very well-organised side."