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The Reds captain returns in a strong starting line-up at Prenton Park, which also includes Roberto Firmino, James Milner, Daniel Sturridge and Georginio Wijnaldum.
Liverpool team in first half: Karius, Alexander-Arnold, Matip, Lucas, Milner, Henderson, Grujic, Wijnaldum, Ojo, Firmino, Sturridge.
Jürgen Klopp will make 10 changes at half-time, introducing the likes of Nathaniel Clyne, Jon Flanagan, Joe Gomez, Ragnar Klavan and Ben Woodburn for the second period.
Liverpool team in second half: Karius, Clyne, Gomez, Klavan, Flanagan, Stewart, Chirivella, Woodburn, Markovic, Kent, Solanke.
Kamil Grabara and Connor Randall are available as additional substitutes.
Dejan Lovren, Alberto Moreno and Divock Origi are not involved due to minor muscle strains.