The 107,000-capacity Michigan Stadium, known as The Big House, is set to host the Premier League foes for their International Champions Cup tie.
It’s a game you can watch live on LFCTV and LFCTV GO (excluding USA) as the Reds take another step in their preparations for the upcoming season.
And with all the factors at play – the opponents, the venue and the need to perform – Lallana expects an event to savour in Ann Arbor.
“Never, no,” the midfielder told Liverpoolfc.com after Friday’s training session when asked if matches against United can ever be considered friendlies.
“None of these games are, especially when you’ve got the atmosphere and the fans here. It just feels like a normal game and I’m sure that will be the same tonight.
“Obviously the opponents have been a lot tougher since we came out to the States. It’s a magnificent stadium. Hopefully it will be full and we’ll have another good run-out.”
LFCTV GO: Lallana looks ahead to United clash
On a personal level, Lallana is carefully building up his fitness and endurance after a 2017-18 campaign that was afflicted by injury for the majority.
The 30-year-old can feel the physical benefits of the past four weeks of intensive training – but how much of the challenge is in the mind, restoring confidence in his own body?
“Maybe it’s just a combination of everything,” replied the England international, who is now getting ready for his fifth season with Liverpool.
“This pre-season is what I needed, five or six weeks to not worry about anything – no competitive games – and get up to speed.
“I feel I’m getting there. I’ve played five [lots of] 45 minutes now so that has been pleasing. Hopefully we can kick on in the next couple of weeks.”
Liverpool’s demanding pre-season schedule is designed to ensure optimal fitness for the players come the beginning of the Premier League at home to West Ham United on August 12.
The meeting with United marks the conclusion of the trip to the United States, with a training camp in France to follow next week before final warm-ups against Napoli and Torino.
“Pre-season is always intense and I think it will go up a notch when we go to France next week,” added Lallana.
“It’s not just training; you’ve got appearances to do and you’re flying from state to state. And the time difference as well.
“But that’s what pre-season is for: it is hard work and we’re here to get fit. You have to do that by working hard.”
Watch LFC take on MUFC in Michigan live on LFCTV and LFCTV GO (not available in USA)>>>