The Continental Tyres Cup tie is set for a 2pm BST kick-off at Prenton Park.
Road closures will be in place due to the Red Bull Drift Shifters event taking place in the city during the day.
Northbound and southbound sides of The Strand - and adjoining roads - will be closed until 6am on Monday August 20 and clearly signed traffic diversion routes will be put in place.
Pedestrian access will be maintained to businesses and residents via the clearly signed pedestrian diversion routes.