Courtney Sweetman-Kirk scored four times - including a hat-trick inside the opening 40 minutes - with Rinsola Babajide also netting before half-time at Havard University.
Babajide quickly added the Reds' sixth after the restart as Vicky Jepson's side ran out convincing winners in Boston.
Read our full match report here and browse through a collection of the best photos of the game below...
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