Kick-off is at 2pm BST and the official matchday magazine is the perfect souvenir for the occasion and is packed full of great content.
Manager Vicky Jepson and captain Sophie Bradley-Auckland share their thoughts in their regular columns and the opening day issue also includes a fabulous centre-page team poster.
Summer signing Becky Jane looks ahead to the clash against her former club, while defender Leighanne Robe reflects on the Reds' pre-season and the challenges of the opening month.
Vice-captain Niamh Fahey shares some dressing room secrets as she gives the lowdown on her teammates, while attacker Rinsola Babajide shares her musical tastes in another new feature.
We also introduce new arrival and cover star Mel Lawley plus fellow newcomer Jade Bailey, include all the news from around the Reds' training base as well as all the facts and stats to keep you in the know.
So make sure you pick up your copy of the official matchday programme at Tranmere on Sunday, priced £3.