The Reds need to win and hope other results go their way to reach the quarter-finals but will be buoyed by an excellent display in Sunday's 1-1 draw with West Ham United.
The official matchday programme is a great souvenir for the occasion and is packed full of great content.
Inside, we hear from midfielder Rhiannon Roberts who reflects on scoring her first Liverpool goal against Blackburn Rovers in the Reds' previous game in the tournament and finishing the game wearing the captain's armband.
Elsewhere, goalkeeper Frances Kitching offers an insight into her teammates while forward Ashley Hodson shares her musical tastes.
Manager Vicky Jepson offers her thoughts in her regular column while captain Sophie Bradley-Auckland also looks ahead to the game in her skipper's notes.
There is a fab pull-out poster of defender Leighanne Robe, the lowdown on our visitors from the North-East, a review of the Continental Cup season so far and all the facts and stats to keep you in the know.
So make sure you pick up your copy of the official matchday programme at Tranmere tonight, priced £3.