Pepe Reina is set to play his 350th game for Liverpool in all competitions and make his 250th league appearance for the club against Wigan Athletic today.

He will become the fifth 'keeper to reach 350 league and cup appearances for the Reds and the sixth to play 250 times in league football.

No custodian has ever kept more clean sheets in their first 250 league games for Liverpool than the Spain international.

Ray Clemence kept 116, Bruce Grobbelaar 111, Elisha Scott 90, Tommy Lawrence 75 and Arthur Riley 47. Reina has 119 to his name in 249 games.

Here are the rest of the facts and figures from club statto Ged Rea.

Head to head (league only):

At Anfield:  Liverpool 4 wins, Wigan 0 wins, 2 draws
Overall:   Liverpool 7 wins, Wigan 1 wins, 5 draws

Earlier this season the sides drew 0-0 at Wigan. It was the first goalless draw between the teams in league football. Charlie Adam had a penalty saved by Ali Al Habsi after 51 minutes.

The sides also drew in the last meeting at Anfield. Raul Meireles scored his fifth goal in six games to give the Reds the lead but Steve Gohouri equalised after 65 minutes.

Liverpool and Wigan have drawn each of the last three meetings.

The Reds have kept one clean sheet in the last eight clashes with the Latics.

Liverpool have failed to score in two of the 13 league meetings.

Liverpool's biggest ever win over our opponents was the 4-0 success at Wigan in December 2006. Craig Bellamy (2) and Dirk Kuyt were among the scorers that day with all four goals coming in the first half.

Kuyt has scored more goals for Liverpool against Wigan than any other player. He has five.

Steve Staunton is the only Liverpool player to score a hat-trick against Wigan, doing so as a second-half substitute at Anfield in October 1989 in a League Cup tie.

Andy Carroll made his career league debut at Wigan in February 2007 - for Newcastle in a 1-0 defeat. 

With his spectacular goal at QPR, Sebastian Coates became the seventh South American national to score for the Reds in the Premier League following Maxi, Luis Suarez, Fabio Aurelio, Mark Gonzalez, Javier Mascherano and Lucas.

The last Liverpool player to score a hat-trick in successive home league games was Fernando Torres who recorded them against Middlesbrough and West Ham in 2007-08.

Only Manchester City (seven) have conceded fewer home league goals this season than Liverpool (10). Swansea also have conceded 10.

As a manager Roberto Martinez has lost just one of his five games against Liverpool.

The Latics' only win over Liverpool in the 13 league meetings came in March 2010 when Hugo Rodallega scored the only goal at Wigan.

Rodallega made his Wigan debut as a substitute at home to Liverpool in January 2009.

He, along with Amr Zaki, is Wigan's leading scorer against Liverpool in the league with two goals.

Wigan have scored eight goals in the 13 league meetings between the teams, but have found the net in seven of the last eight games against Liverpool.

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They have picked up eight points out of 39 in their league history against the Reds.

Wigan are unbeaten in their last four games against Liverpool and have conceded just twice in that time.

A victory will see Wigan become the 51st different visiting team to beat Liverpool at Anfield in the league.

Antolin Alcaraz played for Paraguay in the 2010 World Cup Finals and scored against Italy in their opening group game.

Emmerson Boyce could make his 150th league appearances for the Latics.

Wigan have drawn four of their last six games in the Premier League with only one defeat.

They have recorded three away league wins this season - at Sunderland (2-1) and West Brom (2-1) in successive away games towards the end of 2011 and Bolton (also 2-1) last month. 

Athletic have won one of their last 14 league games since beating West Brom three months ago.

Only Blackburn (33) have conceded more away goals in the top-flight this season than Wigan (and Bolton -both 29) while only Fulham and Stoke have scored fewer away than the Latics who have scored 13.

Current League Positions:

Liverpool: Pld 29, won 11, drawn 9, lost 9, goals for 35, against 29, points 42, position: 7th
Wigan: Pld 29, won 4, drawn 10, lost 15, goals for 25, against 54, points 22, position: 19th

Leading scorers this season (league in brackets): 

Liverpool: Suarez 11 (6), Bellamy 9 (6), Gerrard 9 (5), Carroll 6 (3), Kuyt 5 (2), Maxi 4 (2), Skrtel 4 (2), Adam 2 (2), Downing 2 (0), Agger 1 (0), Coates 1 (1), Henderson 1 (1), Johnson 1 (1), Kelly 1 (0), Shelvey 1 (0), own goals 6 (4)

Wigan: Di Santo 4 (4), Gomez 4 (4), Watson 4 (3), McArthur 3 (3), Moses 3 (3), Caldwell 2 (2), Diame 2 (2), Rodallega 2 (2), Crusat 1 (1), McManaman 1 (0), own goals 1 (1)